most recent 30 from http://www.skepticexchange.org 2010-07-30T02:43:59Z http://www.skepticexchange.org/feeds/question/159 http://www.creativecommons.org/licenses/by-nc/2.5/rdf http://www.skepticexchange.org/questions/159/can-data-show-if-h1n1-vaccine-was-truly-effective Rob T. 2009-12-14T16:28:23Z 2010-01-21T17:07:10Z

<p>When the H1N1 flu season is over, will there be any hard data to show the efficacy of the vaccine?</p> <p>Without that, there's really no scientific way (or is there?) to tell whether the people who remained healthy did so because:</p> <ul> <li>the vaccine was effective or...</li> <li>the flu wasn't "all that bad".</li> </ul>

http://www.skepticexchange.org/questions/159/can-data-show-if-h1n1-vaccine-was-truly-effective/161#161 Joshua DeWald 2009-12-14T18:09:37Z 2009-12-14T18:09:37Z

<p>Speaking completely hypothetically I could imagine that a "cohort" (I believe that's the proper term here) study could be done where they randomly survey people and ask them:</p> <ol> <li>Were you vaccinated for H1N1?</li> <li>Did you become infected with H1N1?</li> <li>Did any of your immediate (living in same household) relatives as you get sick with H1N1?</li> <li>Did any of your co-workers get sick with H1N1?</li> </ol> <p>They can then analyze (controlling for age, gender, etc) whether the incidence of infection was drastically influenced for those around others who had been infected based on whether or not they were vaccinated (2 weeks prior to the contact at least). </p> <p>Preferably they can then also ask the relatives and co-workers, allowing for the actual infection network to be analyzed (i.e... if an most of entire office was good about vaccinating, they could significantly have impacted the spread to their immediate family).</p> <p>It is possible this is already how they test effectiveness.</p>

http://www.skepticexchange.org/questions/159/can-data-show-if-h1n1-vaccine-was-truly-effective/170#170 Skrivener 2009-12-16T02:14:38Z 2009-12-16T02:14:38Z

<p>Further to Joshua's good answer, the H1N1 vaccine is based on the existing flu vaccine model, which has a great deal of supporting data. It's essentially the same, just targeting a different strain of influenza, so there is every reason to believe it is effective even without extensive testing. However, <a href="http://www.virology.ws/2009/10/20/influenza-a-h1n1-2009-vaccine-efficacy-and-safety/" rel="nofollow">here is some information as to safety and efficacy trials</a>.</p> <blockquote> <p>By day 21 after vaccination, HI antibody titers of 1:40 or more were observed in 116 (97%) of 120 adults who received a 15 μg dose.</p> </blockquote>